Increasing Distribution of Drugs Released from In Situ Forming PLGA Implants Using Therapeutic Ultrasound
| Autor: | Christopher Hernandez, Agata A. Exner, Norased Nasongkla, Selva Jeganathan, Pinunta Nittayacharn, Chawan Manaspon |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science medicine.medical_treatment Biomedical Engineering 02 engineering and technology Article Imaging phantom High-Energy Shock Waves Diffusion Sonication 03 medical and health sciences chemistry.chemical_compound Polylactic Acid-Polyglycolic Acid Copolymer medicine Tissue Distribution Lactic Acid Therapeutic ultrasound business.industry Ultrasound Penetration (firestop) 021001 nanoscience & nanotechnology Controlled release PLGA 030104 developmental biology chemistry Delayed-Action Preparations Drug delivery Fluorescein Implant 0210 nano-technology business Polyglycolic Acid Biomedical engineering |
| Zdroj: | Annals of Biomedical Engineering. 45:2879-2887 |
| ISSN: | 1573-9686 0090-6964 |
| Popis: | One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2.2 W/cm2 for 10 minutes. The 2D distribution of fluorescein within the phantoms was quantified using fluorescence imaging. Implants receiving ultrasound irradiation showed a 1.7-5.6 fold increase (p < 0.05) in fluorescence intensity and penetration distance, with the maximum increase observed 5 days post-implantation. However, this evidence was not seen when the same experiment was also carried out in phosphate buffer saline (pH 7.4). Results suggest an active role of ultrasound in local molecular transport in the phantom. An increase of fluorescein release and penetration depth in phantoms can be accomplished through brief application of ultrasound. This simple technique offers an opportunity to eventually enhance the therapeutic efficacy and broaden the application of local drug delivery systems. |
| Databáze: | OpenAIRE |
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