Effect of genetic polymorphisms in SREBF–SCAP pathway on therapeutic response to rosuvastatin in Saudi metabolic syndrome patients
| Autor: | Misbahuddin M Rafeeq, Z.J. Gazzaz, Murad Has, M A Gari, Hamed S. Habib |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Genotype Population 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Genetics medicine Humans Rosuvastatin Prospective Studies Rosuvastatin Calcium Allele education Cholesterol homeostasis Metabolic Syndrome Pharmacology education.field_of_study business.industry Intracellular Signaling Peptides and Proteins Genetic variants Membrane Proteins Middle Aged medicine.disease Lipids Obesity 030104 developmental biology Molecular Medicine Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Metabolic syndrome Sterol Regulatory Element Binding Protein 1 business Signal Transduction medicine.drug |
| Zdroj: | Pharmacogenomics. 19:185-196 |
| ISSN: | 1744-8042 1462-2416 |
| Popis: | Aim: Genetic variants contribute to statins’ therapeutic variability. SREBF–SCAP pathway is a key player in lipid homeostasis. Hence, effect of SREBF–SCAP polymorphisms on therapeutic response was studied. Patients & methods: Metabolic syndrome patients of either sex were prescribed rosuvastatin 10 mg for 24 weeks. Clinical, anthropometric and lipid measurements were done before and after treatment. Genotyping was done by pyrosequencing. Results & conclusion: No associations of SCAP and SREBF-1a genotypes with baseline lipids but significant associations with lipid reductions were observed. Significant effect of SCAP (GG; B = -8.16, p = 0.001); SREBF-1a (GG; B = -7.47, p = 0.001) and SREBF-1a (-delG; B = -7.42, p = 0.001) was observed on total cholesterol reduction. Additive trend was found between SCAP genotypes and lipid reductions. A total of 88% responders have SCAP ‘G’ allele (p = 0.001). Patients carrying SCAP (GG) and SREBF-1a (GG and -delG) have 9.5-, 8.6- and 14.6-times more likelihood of being responders (p |
| Databáze: | OpenAIRE |
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