Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids
| Autor: | Hyunhee Kim, Daiyoon Lee, Shaf Keshavjee, Shaun Pacheco, Hong Yang, Shuyun Xu, Jinbo Zhao, Mingyao Liu |
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| Rok vydání: | 2015 |
| Předmět: |
Metal Nanoparticles
Nanoparticle Peptide Pharmacology Lung injury Biology Cell Line In vivo Animals Humans General Materials Science Amino Acid Sequence Particle Size Protein Kinase Inhibitors Peptide sequence chemistry.chemical_classification Drug Carriers Microscopy Confocal In vitro Rats Disease Models Animal Protein Kinase C-delta chemistry Cell culture Reperfusion Injury Biophysics Gold Peptides Intracellular |
| Zdroj: | Nanoscale. 7:12356-12360 |
| ISSN: | 2040-3372 2040-3364 |
| Popis: | A novel gold nanoparticle-peptide hybrid strategy was developed to intracellularly deliver a potent PKCδ inhibitor peptide for the treatment of acute lung injury. The gold nanoparticle-peptide hybrids showed good stability with high uptake, and demonstrated in vitro and in vivo efficacy. Our formulation strategy shows great promise in intracellular delivery of peptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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