X-Ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster
| Autor: | Paul V. Harris, James B. Boyd, Douglas R. Oliveri |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
DNA Repair
DNA repair Mutant DNA Single-Stranded Mutagen Toxicology medicine.disease_cause Radiation Tolerance chemistry.chemical_compound Drosophilidae Genetics medicine Animals Molecular Biology X-RAY SENSITIVITY Mutation biology X-Rays biology.organism_classification Cell biology Kinetics Drosophila melanogaster chemistry DNA Mutagens |
| Zdroj: | Mutation Research/DNA Repair. 235:25-31 |
| ISSN: | 0921-8777 |
| Popis: | Mutants of Drosophila melanogaster that are sensitive to chemical mutagens were analyzed for sensitivity to X-rays and for the capacity to repair single-strand DNA breaks induced by X-rays. Analysis of X-ray sensitivity demonstrated that 74% of the mutants assayed display some X-ray sensitivity, with 75% of the sensitive lines being extremely sensitive. Repair of single-strand breaks was assayed after both high and low doses of irradiation in order to permit detection of repair over a wide range of damage. The results of this investigation fail to show a correlation between X-ray sensitivity and this particular repair process. Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection. |
| Databáze: | OpenAIRE |
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