The multifaceted roles of tumor-associated proteases and harnessing their activity for prodrug activation
| Autor: | Olga Vasiljeva, Michael B. Winter, Stephen James Moore, Daniel R. Hostetter |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tumor microenvironment Proteases Stromal cell Clinical Biochemistry Proteolytic enzymes Cancer Biology medicine.disease Biochemistry Metastasis Extracellular matrix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Cancer cell Cancer research medicine Molecular Biology |
| Zdroj: | Biological chemistry. |
| ISSN: | 1437-4315 |
| Popis: | The role of proteases in cancer was originally thought to be limited to the breakdown of basement membranes and extracellular matrix (ECM), thereby promoting cancer cell invasion into surrounding normal tissues. It is now well understood that proteases play a much more complicated role in all stages of cancer progression and that not only tumor cells, but also stromal cells are an important source of proteases in the tumor microenvironment. Among all the proteolytic enzymes potentially associated with cancer, some proteases have taken on heightened importance due to their significant up-regulation and ability to participate at multiple stages of cancer progression and metastasis. In this review, we discuss some of the advances in understanding of the roles of several key proteases from different classes in the development and progression of cancer and the potential to leverage their upregulated activity for the development of novel targeted treatment strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|