A Comparison of Pivmecillinam/Pivampicillin and Amoxycillin in Acute Exacerbations of Chronic Bronchitis
| Autor: | D. J. Talbot, M. J. Atkins |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Chronic bronchitis Adolescent medicine.drug_class medicine.medical_treatment Antibiotics Peak Expiratory Flow Rate Biochemistry Pivampicillin chemistry.chemical_compound Internal medicine polycyclic compounds medicine Humans Bronchitis Clinical Trials as Topic Chemotherapy Sputum colour business.industry Incidence (epidemiology) digestive oral and skin physiology Biochemistry (medical) Sputum Amdinocillin Amoxicillin Amdinocillin Pivoxil Cell Biology General Medicine Middle Aged medicine.disease Anti-Bacterial Agents Surgery Drug Combinations Pivmecillinam chemistry Acute Disease Chronic Disease Ampicillin Female business medicine.drug |
| Zdroj: | Journal of International Medical Research. 15:115-120 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006058701500209 |
| Popis: | Courses of 7 days on either 200 mg pivmecillinam/250 mg pivampicillin given twice daily or 250 mg amoxycillin given three times daily were compared in 3783 general practice patients with acute exacerbations of chronic bronchitis in a single-blind parallel group study. Patients on pivmecillinam/pivampicillin had significantly more ‘excellent’ responses, although there was no difference in overall response between treatments. Post-treatment sputum colour and consistency and peak expiratory flow rates were significantly better with pivmecillinam/pivampicillin. The incidence of side-effects was the same for both groups (approximately 10%), although significantly more patients reported lower gastro-intestinal problems with amoxycillin. Treatment was withdrawn due to side-effects in 47 (2.5%) patients on pivmecillinam/pivampicillin and 51 (2.7%) patients on amoxycillin. Amoxycillin is a standard therapy in the treatment of patients with acute exacerbations of chronic bronchitis. In this study, however, it was shown that pivmecillinam/pivampicillin offers benefits over amoxycillin in these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|