The early diversification of influenza A/H1N1pdm
Autor: | Timothy B. Stockwell, Cécile Viboud, Erin Hine, Eric T. Beck, Rebecca A. Halpin, David J. Spiro, Xudong Lin, Kathleen Proudfoot, Sara Griesemer, Elodie Ghedin, David E. Wentworth, Martha I. Nelson, Edward C. Holmes, Michael E. Bose, Jiang Fan, Kelly J. Henrickson, Swati Kumar, Jayati Bera |
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Rok vydání: | 2009 |
Předmět: |
0303 health sciences
education.field_of_study Phylogenetic tree 030306 microbiology business.industry Population Medicine (miscellaneous) Diversification (marketing strategy) Influenza 3. Good health 03 medical and health sciences Evolutionary biology Pandemic Spatial ecology Medicine Clade education business Evolutionary dynamics 030304 developmental biology Founder effect |
Zdroj: | PLoS Currents |
ISSN: | 2157-3999 |
DOI: | 10.1371/currents.rrn1126 |
Popis: | Background Since its initial detection in April 2009, the A/H1N1pdm influenza virus has spread rapidly in humans, with over 5,700 human deaths. However, little is known about the evolutionary dynamics of H1N1pdm and its geographic and temporal diversification. Methods Phylogenetic analysis was conducted upon the concatenated coding regions of whole-genome sequences from 290 H1N1pdm isolates sampled globally between April 1 – July 9, 2009, including relatively large samples from the US states of Wisconsin and New York. Results At least 7 phylogenetically distinct viral clades have disseminated globally and co-circulated in localities that experienced multiple introductions of H1N1pdm. The epidemics in New York and Wisconsin were dominated by two different clades, both phylogenetically distinct from the viruses first identified in California and Mexico, suggesting an important role for founder effects in determining local viral population structures. Conclusions Determining the global diversity of H1N1pdm is central to understanding the evolution and spatial spread of the current pandemic, and to predict its future impact on human populations. Our results indicate that H1N1pdm has already diversified into distinct viral lineages with defined spatial patterns. |
Databáze: | OpenAIRE |
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