Crustacean leg regeneration restores complex microanatomy and cell diversity
| Autor: | Almazán, Alba, Çevrim, Çağrı, Musser, Jacob M., Averof, Michalis, Paris, Mathilde |
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| Přispěvatelé: | Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), EMBL Heidelberg |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Science Advances Science Advances, 2022, 8 (34), pp.eabn9823. ⟨10.1126/sciadv.abn9823⟩ |
| ISSN: | 2375-2548 |
| Popis: | Animals can regenerate complex organs, yet this process frequently results in imprecise replicas of the original structure. In the crustacean Parhyale , embryonic and regenerating legs differ in gene expression dynamics but produce apparently similar mature structures. We examine the fidelity of Parhyale leg regeneration using complementary approaches to investigate microanatomy, sensory function, cellular composition, and cell molecular profiles. We find that regeneration precisely replicates the complex microanatomy and spatial distribution of external sensory organs and restores their sensory function. Single-nuclei sequencing shows that regenerated and uninjured legs are indistinguishable in terms of cell-type composition and transcriptional profiles. This remarkable fidelity highlights the ability of organisms to achieve identical outcomes via distinct processes. |
| Databáze: | OpenAIRE |
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