Association of liver enzymes with incident diabetes in US Hispanic/Latino adults
| Autor: | Qibin Qi, Simin Hua, Martha L. Daviglus, Jianwen Cai, Bharat Thyagarajan, Neil Schneiderman, Robert C. Kaplan, Jessica Williams-Nguyen, Gregory A. Talavera, Carmen R. Isasi, Jorge R. Kizer, Howard D. Strickler, Scott J. Cotler |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Disease Risk Assessment digestive system Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Liver Function Tests Non-alcoholic Fatty Liver Disease Risk Factors Diabetes mellitus Internal medicine Odds Ratio Internal Medicine Humans Medicine Aspartate Aminotransferases Prospective Studies 030212 general & internal medicine Prospective cohort study Aged business.industry Incidence Fatty liver Alanine Transaminase Hispanic or Latino gamma-Glutamyltransferase Middle Aged Hepatitis B medicine.disease Obesity United States digestive system diseases Diabetes Mellitus Type 2 Liver Quartile Relative risk Female business Follow-Up Studies |
| Zdroj: | Diabetic Medicine. 38 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/dme.14522 |
| Popis: | INTRODUCTION Non-alcoholic fatty liver disease (NAFLD) has been associated with increased risk of incident diabetes. But such evidence is lacking in the Hispanic/Latino population, which has high prevalence of obesity and NAFLD. METHODS We conducted a prospective cohort study of 6,928 adults of Hispanic/Latino background who had no diabetes, did not report excessive alcohol use, and no hepatitis B and C infection at baseline (2008-2011). We estimated risk ratios (RR) for incident diabetes, identified from visit 2 examination by glucose measurements or antidiabetic medication use, with baseline liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)). RESULTS A total of 738 adults developed diabetes during 6 years of follow-up. After adjusting for participant characteristics at baseline, versus the lowest quartile, highest quartiles of ALT and GGT were associated with risks for incident diabetes (RR for ALT: 1.51 [95% CI 1.03-2.22], p-trend = 0.006; RR for GGT: 2.39 [1.60-3.55], p-trend = 0.001). Higher GGT levels predicted increased risk of incident diabetes even among those with ALT or AST below the median levels. The associations of ALT and GGT with incident diabetes were similar among most Hispanic background but were not seen among Dominicans (p for interaction |
| Databáze: | OpenAIRE |
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