Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
| Autor: | Ronell Bologna-Molina, Setién-Olarra A, Adalberto Mosqueda-Taylor, María del Carmen González-Galván, José-Manuel Aguirre-Urizar, Xabier Marichalar-Mendia |
|---|---|
| Přispěvatelé: | González Galván María del Carmen, Mosqueda Taylor Adalberto, Bologna Molina Ronell, Setien Olarra Amaia, Marichalar Mendia Xabier, Aguirre Urizar José Manuel, González-Galván MC, Universidad Nacional de Asunción (Paraguay), Mosqueda-Taylor A., Universidad Autónoma Metropolitana. Unidad Xochimilco (México), Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología, Setien-Olarra A., Universidad del País Vasco (España). Facultad de Medicina y Enfermería., Marichalar-Mendia Xabier, Universidad del País Vasco (España). Facultad de Medicina y Enfermería., Aguirre-Urizar JM, Universidad del País Vasco (España). Facultad de Medicina y Enfermería. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
Male Odontogenic myxoma RANK-L RANK 03 medical and health sciences 0302 clinical medicine Osteoprotegerin Osteoclastogenesis Medicine Neoplasm Humans MIXOMA Receptor General Dentistry Language OSTEOGENESIS Dental follicle Oral Medicine and Pathology biology Activator (genetics) business.industry Research 030206 dentistry CIENCIAS MÉDICAS [UNESCO] medicine.disease LIGANDO RANK Otorhinolaryngology RANKL 030220 oncology & carcinogenesis UNESCO::CIENCIAS MÉDICAS Cancer research biology.protein Immunohistochemistry OPG Surgery business Myxoma |
| Zdroj: | Medicina Oral, Patología Oral y Cirugía Bucal COLIBRI Universidad de la República instacron:Universidad de la República Gonzalez Galvan, Maria del Carmen ; Mosqueda Taylor, Adalberto ; Bologna Molina, Ronell ; Setién Olarra, Amaia ; Marichalar Mendia, Xabier ; Aguirre Urízar, José Manuel. Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 3 2018: 9 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| ISSN: | 1698-6946 1698-4447 |
| Popis: | Background Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and Methods Eighteen OMs, 4 small ( 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANKL and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas. Key words:Odontogenic myxoma, dental follicle, RANK, RANK-L, OPG, osteoclastogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|