In vitro microbiological evaluation of 1,1'-(5,5'-(1,4-phenylene)bis(3-aryl-1H-pyrazole-5,1-(4H,5H)-diyl))diethanones, novel bisacetylated pyrazoles
| Autor: | V. Kanagarajan, Mannathusamy Gopalakrishnan, Muthuvel R. Ezhilarasi |
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| Jazyk: | angličtina |
| Předmět: |
Original
Organic Chemistry Microsporum gypseum Aspergillus flavus Biology biology.organism_classification medicine.disease medicine.disease_cause Antimicrobial bisacetylated pyrazoles Microbiology Shigella flexneri in situ acetylation antibacterial activity Staphylococcus aureus medicine Pharmacology (medical) Klebsiella pneumonia Micrococcus luteus Antibacterial activity antifungal activity antitubercular activity |
| Zdroj: | Organic and Medicinal Chemistry Letters |
| ISSN: | 2191-2858 |
| DOI: | 10.1186/2191-2858-1-8 |
| Popis: | Novel 1,1'-(5,5'-(1,4-phenylene)bis(3-aryl-1H-pyrazole-5,1-(4H,5H)-diyl))diethanones 7-12 were tested for their antimicrobial activity by disc diffusion and twofold serial dilution method against the tested bacterial and fungal strains. Compounds 7 against Micrococcus luteus, 8 against β-Heamolytic streptococcus, M. luteus, Klebsiella pneumonia, Microsporum gypseum, 9 against Staphylococcus aureus, Shigella flexneri, Vibreo cholerae, Pseudomonas aeruginosa, Aspergillus flavus, Mucor indicus, 10 against Salmonella typhii, S. flexneri, M. gypseum, 11 against K. pneumonia, M. gypseum, 12 against K. pneumonia, and M. gypseum show superior zone of inhibitions and exhibited excellent antibacterial and antifungal activities at a MIC value of 6.25 μg/mL. Moreover, all the tested compounds 7-12 revealed promising antitubercular activity against Mycobacterium tuberculosis H37Rv and INH-resistant M. tuberculosis. Compounds 8 against M. tuberculosis and 11 against INH-resistant M. tuberculosis exhibited the percentage of reduction in RLU at 89 and 85%, respectively. |
| Databáze: | OpenAIRE |
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