Hederacoside-C protects against AGEs-induced ECM degradation in mice chondrocytes
| Autor: | Bin Wu, Zhong-hai Shen, Yi-ming Ma, Hai-chao Xu, Hao Xu, Chen Sheng |
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| Rok vydání: | 2020 |
| Předmět: |
Glycation End Products
Advanced Male 0301 basic medicine Cell Survival Immunology Anti-Inflammatory Agents Down-Regulation Inflammation Protective Agents Hederacoside C Chondrocyte 03 medical and health sciences Chondrocytes 0302 clinical medicine Downregulation and upregulation Glycation Osteoarthritis medicine Animals Immunology and Allergy Oleanolic Acid Cells Cultured Pharmacology Interleukin-6 Tumor Necrosis Factor-alpha Chemistry NF-kappa B Ecm degradation In vitro experiment Extracellular Matrix Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female medicine.symptom Signal transduction Reactive Oxygen Species Signal Transduction |
| Zdroj: | International Immunopharmacology. 84:106579 |
| ISSN: | 1567-5769 |
| Popis: | Hederacoside-C (HDC), a natural compound extracted from the leaves of Hedera helix with inflammation modulatory properties in variety of disorders. In this study, we investigated the latent mechanism of HDC in alleviating of the progress of OA in vitro experiment. The results showed that HDC pretreatment suppressed the advanced glycation end-products (AGEs) induced over-regulation of ROS level and inflammatory factors. Moreover, HDC also downregulate the degradation of ECM induced by AGEs. Mechanistically, the HDC suppressed NF-κB signaling pathway in chondrocyte. To sum up, this study indicated HDC possessed a new potential therapeutic option in osteoarthritis. |
| Databáze: | OpenAIRE |
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