| Autor: |
Asfar S. Azmi, Anthony F. Shields, Ramzi M. Mohammad, Philip A. Philip, Dipesh Uprety, Hirva Mamdani, Yosef Landesman, Rafic Beydoun, Steve Kim, Mohammed Najeeb Al-Hallak, Yousef Mzannar, Sahar Bannoura, Rachel Sexton, Md. Hafiz Uddin, Amro Aboukameel, Yiwei Li, Misako Nagasaka, Husain Yar Khan |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure 1. XPO1-KRAS synthetic lethal interaction identified using the Slorth database. Supplementary Figure 2. KRAS WT, KRAS G12D and KRAS G12V MEF cell lines were refractory to growth inhibition by selinexor or MRTX1257 or their combinations. Supplementary Figure 3. KRAS G12D mutant PDAC cell line Panc-1 was refractory to growth inhibition by KRAS G12C inhibitor AMG510. Supplementary Figure 4. Body weights of mice xenografted with MiaPaCa2 tumors were measured during the treatment period. Supplementary Table 1. Sequences of primers used. Supplementary Table 2. Combination Index (CI) values at various dose combinations of the drugs tested on different KRAS G12C mutant cell lines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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