Cholesterol‐independent endothelial dysfunction in virgin and pregnant rats fed a diet high in saturated fat
| Autor: | Ivan O'Brien‐Coker, Lucilla Poston, Rita van Bree, Robert T. Gerber, Kathleen Holemans, F. André Van Assche, A. I. Mallet |
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| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endothelium Physiology Saturated fat Adipose tissue Fatty Acids Nonesterified Biology Dinoprost medicine.disease_cause chemistry.chemical_compound Pregnancy Reference Values Internal medicine mental disorders medicine Animals Insulin Rats Wistar Endothelial dysfunction Mesenteric arteries Triglycerides F2-Isoprostanes Cholesterol Fatty Acids Original Articles medicine.disease Dietary Fats Rats medicine.anatomical_structure Endocrinology Adipose Tissue chemistry Body Composition Pregnancy Animal Female Endothelium Vascular Oxidative stress Corn oil |
| Zdroj: | The Journal of Physiology. 517:607-616 |
| ISSN: | 1469-7793 0022-3751 |
| DOI: | 10.1111/j.1469-7793.1999.0607t.x |
| Popis: | 1. Western diets high in saturated fat are associated with an increased incidence of cardiovascular diseases. In this study we have evaluated vascular endothelial function and oxidative stress in virgin rats fed a normal (VC) or high in saturated fat diet (VHF) (20 % lard and corn oil w/w) from weaning until adulthood, and throughout subsequent pregnancy (PC and PHF, respectively). 2. The saturated fat diet was associated with enhanced noradrenaline sensitivity in small mesenteric arteries from VHF rats (VHF vs. VC, P < 0.05) and blunted endothelium-dependent relaxation in VHF and PHF rats (VHF vs. VC, P < 0.001; PHF vs. PC, P < 0.05). Endothelial dysfunction was attributable to a reduced nitric oxide component of relaxation in VHF rats, and blunted prostacyclin and endothelium-derived hyperpolarizing factor components in PHF rats. 3. Other than plasma cholesterol, which was reduced in VHF and PHF rats, plasma lipids were normal. Fasting plasma insulin and glucose concentrations were raised in VHF rats (P < 0.05) and the plasma marker of oxidative stress, 8-iso PGF2alpha, was increased in PHF animals (P < 0.01). 4. These findings suggest that endothelial dysfunction induced by a saturated fat diet is cholesterol independent and likely to be of different mechanistic origin in virgin and pregnant rats. |
| Databáze: | OpenAIRE |
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