The effect of rate of loading on the strength of tablets

Autor:	E. T. Cole, John A. Hersey, J. E. Rees
Rok vydání:	1970
Předmět:	Pharmacology Materials science Pharmaceutical Science Lactose Standard deviation Breaking strength Microcrystalline cellulose Crystallography chemistry.chemical_compound chemistry Hardness Loading rate Technology Pharmaceutical Powders Composite material Cellulose Tablets
Zdroj:	Journal of Pharmacy and Pharmacology. 22:64S-69S
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1970.tb08582.x
Popis:	The breaking strength of tablets containing lactose and microcrystalline cellulose has been determined using an Instron Universal Testing Instrument at loading rates corresponding to cross-head movements of 0·05 to 5·0 cm min−1. For tablets of 2 to 30 kg, nominal strength, an increase in the loading rate produced a significant increase in the breaking strength, although the absolute increase in the mean strength value was only 2 kg for the strongest tablets. The standard deviation of replicate values was apparently unaffected by loading rate. Results obtained using the motorized Heberlein and Erweka instruments to determine the strength of compressed tablets, indicated that discrepancies in the strength values may be partially attributed to differences in the rates of loading.
Databáze:	OpenAIRE
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