Bilateral proptosis and bitemporal swelling: A rare manifestation of acute myeloid leukemia
| Autor: | Dinesh Rajput, Ram Naval, Kamlesh Yadav, Arun Tungaria, Sanjay Behari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Chemotherapy
Pathology medicine.medical_specialty Acute myeloid leukemia medicine.diagnostic_test business.industry General Neuroscience medicine.medical_treatment proptosis Myeloid leukemia Early detection Case Report chemotherapy medicine.anatomical_structure hemic and lymphatic diseases Pediatrics Perinatology and Child Health Lateral orbital wall Biopsy medicine Bone marrow Swelling medicine.symptom business Leukemic Blasts bitemporal swelling |
| Zdroj: | Journal of Pediatric Neurosciences |
| ISSN: | 1998-3948 1817-1745 |
| Popis: | Background: In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of bilateral proptosis and bilateral temporal swelling in AML is being reported. Case Report: A 6-year-old girl presented with low-grade fever, progressively increasing bitemporal swelling and bilateral proptosis. Contrast Enhanced Computed Tomographic (CECT) images revealed enhancing infiltrates occupying the lateral orbital wall, causing proptosis. The infiltrate extended toward the bilateral temporal fossae beneath the temporalis muscle and extradurally beneath the frontal and temporal bones. A high total leucocytic count with immature and deformed cells and, Fine Needle Aspiration Cytology (FNAC) from the temporal swelling, the bone marrow aspirate and biopsy showing leukemic blast cells confirmed the diagnosis of AML. Chemotherapy brought about remission of the disease. Conclusions: To the best of the authors' knowledge, simultaneous presence of both bilateral proptosis and bitemporal swellings have not been previously reported in AML. A peripheral blood smear with bone marrow aspirate and biopsy help in the early detection of AML. Institution of early intervention in this potentially fatal disease is often associated with gratifying survival rates. |
| Databáze: | OpenAIRE |
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