Versatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseases

Autor: Clara Sanjurjo-Rodríguez, María Piñeiro-Ramil, R. Castro-Viñuelas, Isaac Fuentes-Boquete, Francisco J. Blanco, Silvia Díaz-Prado, Silvia Rodríguez-Fernández
Rok vydání: 2020
Předmět:
OSTEOGENIC DIFFERENTIATION
muscle
Chemistry
Multidisciplinary
Review
Regenerative Medicine
Regenerative medicine
bone
lcsh:Chemistry
Translational Research
Biomedical
Musculoskeletal Diseases
Induced pluripotent stem cell
cartilage
lcsh:QH301-705.5
Spectroscopy
PHENOTYPIC TRAITS
Cell Differentiation
General Medicine
MARFAN-SYNDROME
Computer Science Applications
Chemistry
medicine.anatomical_structure
Organ Specificity
Physical Sciences
Muscle
Life Sciences & Biomedicine
IN-VIVO REPAIR
Pluripotency
Cell type
Biochemistry & Molecular Biology
Induced Pluripotent Stem Cells
iPSCs
Catalysis
CLINICAL-TRIAL
Inorganic Chemistry
medicine
Humans
Physical and Theoretical Chemistry
Bone
Molecular Biology
EVs
Science & Technology
business.industry
Cartilage
Organic Chemistry
Tissue repair
pluripotency
Intervertebral disc
lcsh:Biology (General)
lcsh:QD1-999
POMPE DISEASE
TISSUE
intervertebral disc
business
Neuroscience
CARTILAGE REPAIR
GENERATION
Stem Cell Transplantation
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 6124, p 6124 (2020)
RUC. Repositorio da Universidade da Coruña
instname
International Journal of Molecular Sciences
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)
ISSN: 1422-0067
Popis: [Abstract] Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders a ecting bone, cartilage and muscle, as well as their potential for tissue repair. Musculoskeletal diseases are one of the major causes of disability worldwide and impose an important socio-economic burden. To date there is neither cure nor proven approach for e ectively treating most of these conditions and therefore new strategies involving the use of cells have been increasingly investigated in the recent years. Nevertheless, some limitations related to the safety and di erentiation protocols among others remain, which humpers the translational application of these strategies. Nonetheless, the potential is indisputable and iPSCs are likely to be a source of di erent types of cells useful in the musculoskeletal field, for either disease modeling or regenerative medicine. In this review, we aim to illustrate the great potential of iPSCs by summarizing and discussing the in vitro tissue regeneration preclinical studies that have been carried out in the musculoskeletal field by using iPSCs. Instituto de Salud Carlos III; PI17/02197 Xunta de Galicia; R2016/036 Xunta de Galicia; R2014/050 Xunta de Galicia; CN2012/142 Xunta de Galicia; GPC2014/048
Databáze: OpenAIRE
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