Quantitative characterization of the imaging limits of diffuse low-grade oligodendrogliomas
| Autor: | Johan Pallud, Pascale Varlet, François-Xavier Roux, Basile Grammaticos, Mathilde Badoual, Fabrice Chrétien, Chloé Gerin, Stephen R. Thomas, Christophe Deroulers, Catherine Oppenheim |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Stereotactic biopsy Biopsy Oligodendroglioma Statistics as Topic Brain Edema Immunoenzyme Techniques 03 medical and health sciences Diffuse Glioma 0302 clinical medicine Glioma Edema medicine Humans Tissues and Organs (q-bio.TO) Retrospective Studies medicine.diagnostic_test Brain Neoplasms business.industry Quantitative Biology - Tissues and Organs Magnetic resonance imaging Middle Aged Image Enhancement Prognosis medicine.disease Magnetic Resonance Imaging 3. Good health Oncology FOS: Biological sciences 030220 oncology & carcinogenesis Basic and Translational Investigations Female Neurology (clinical) Imaging Signal Neoplasm Grading medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neuro-Oncology. 15:1379-1388 |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/not072 |
| Popis: | Background : Supratentorial diffuse low-grade gliomas in adults extend beyond maximal visible MRI-defined abnormalities, and a gap exists between the imaging signal changes and the actual tumor margins. Direct quantitative comparisons between imaging and histological analyses are lacking to date. However, they are of the utmost importance if one wishes to develop realistic models for diffuse glioma growth. Methods : In this study, we quantitatively compare the cell concentration and the edema fraction from human histological biopsy samples (BSs) performed inside and outside imaging abnormalities during serial imaging-based stereotactic biopsy of diffuse low-grade gliomas. Results : The cell concentration was significantly higher in BSs located inside (1189 $\pm$ 378 cell/mm$^2$) than outside (740 $\pm$ 124 cell/mm$^2$) MRI-defined abnormalities (p=0.0003). The edema fraction was significantly higher in BSs located inside (mean, 45 $\pm$ 23%) than outside (mean, 5 $\pm$ 9%) MRI-defined abnormalities (p 19 pages, 1 table, 6 figures, 1 supplementary figure |
| Databáze: | OpenAIRE |
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