Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma

Autor: Feiran Wei, Xuerong Wang, Wei Li, You Ge, Baoan Chen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Pulmonary and Respiratory Medicine
MAPK/ERK pathway
Lung Neoplasms
Adenocarcinoma of Lung
medicine.disease_cause
EDNRB
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Cell Movement
Glioma
Biomarkers
Tumor
Tumor Cells
Cultured
Medicine
Humans
Gene
Survival rate
Cell Proliferation
Lung
GSEA
integumentary system
business.industry
Erk signaling pathway
General Medicine
Original Articles
TCGA
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
lung adenocarcinoma
Prognosis
Receptor
Endothelin B
Gene Expression Regulation
Neoplastic
Survival Rate
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cancer research
Adenocarcinoma
Original Article
business
Endothelin receptor
Carcinogenesis
Zdroj: Thoracic Cancer
Thoracic Cancer, Vol 11, Iss 7, Pp 1885-1890 (2020)
ISSN: 1759-7714
1759-7706
Popis: Background The five-year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive value of EDNRB on LUAD. Methods Survival analyses was performed to assess the correlation between EDNRB expression and survival of LUAD patients from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) datasets. Gene set enrichment analysis (GSEA) was conducted to illustrate possible biological functions of EDNRB. Laboratory methods were used to verify the function of EDNRB in LUAD. Results The TCGA results showed that a low expression of EDNRB was found in LUAD patients which led to poor outcome and worse survival, compared with the high expression in GSEA results which suggested that expression of EDNRB might be associated with regulation of the ERK pathway. Laboratory results suggested that EDNRB could inhibit the proliferation and migration of LUAD H1299 cells. Conclusions EDNRB is a potential prognostic marker for LUAD patients and might exert its functions by regulating the ERK pathway in LUAD.
Databáze: OpenAIRE
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