Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
Autor: | Feiran Wei, Xuerong Wang, Wei Li, You Ge, Baoan Chen |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine MAPK/ERK pathway Lung Neoplasms Adenocarcinoma of Lung medicine.disease_cause EDNRB lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Cell Movement Glioma Biomarkers Tumor Tumor Cells Cultured Medicine Humans Gene Survival rate Cell Proliferation Lung GSEA integumentary system business.industry Erk signaling pathway General Medicine Original Articles TCGA medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lung adenocarcinoma Prognosis Receptor Endothelin B Gene Expression Regulation Neoplastic Survival Rate 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Adenocarcinoma Original Article business Endothelin receptor Carcinogenesis |
Zdroj: | Thoracic Cancer Thoracic Cancer, Vol 11, Iss 7, Pp 1885-1890 (2020) |
ISSN: | 1759-7714 1759-7706 |
Popis: | Background The five-year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive value of EDNRB on LUAD. Methods Survival analyses was performed to assess the correlation between EDNRB expression and survival of LUAD patients from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) datasets. Gene set enrichment analysis (GSEA) was conducted to illustrate possible biological functions of EDNRB. Laboratory methods were used to verify the function of EDNRB in LUAD. Results The TCGA results showed that a low expression of EDNRB was found in LUAD patients which led to poor outcome and worse survival, compared with the high expression in GSEA results which suggested that expression of EDNRB might be associated with regulation of the ERK pathway. Laboratory results suggested that EDNRB could inhibit the proliferation and migration of LUAD H1299 cells. Conclusions EDNRB is a potential prognostic marker for LUAD patients and might exert its functions by regulating the ERK pathway in LUAD. |
Databáze: | OpenAIRE |
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