Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes: ADDITION-Denmark
| Autor: | Troels S. Jensen, Páll Karlsson, Ioannis N. Petropoulos, Rayaz A. Malik, Signe T Andersen, Morten Charles, Niels Trolle Andersen, Hatice Tankisi, Henning Andersen, Kasper Grosen |
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| Rok vydání: | 2018 |
| Předmět: |
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Diabetic polyneuropathy medicine.medical_specialty Corneal nerve Denmark Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Diabetic complication law.invention Cohort Studies Cornea 03 medical and health sciences Nerve Fibers 0302 clinical medicine Endocrinology Diabetic Neuropathies Predictive Value of Tests Confocal microscopy law Diabetes mellitus Ophthalmology Internal Medicine medicine Humans Mass Screening Aged Diabetic Retinopathy Microscopy Confocal Screen detected business.industry Diabetes Toronto consensus criteria Prognosis medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Corneal confocal microscopy Case-Control Studies Cohort Female Fiber density business 030217 neurology & neurosurgery |
| Zdroj: | Andersen, S T, Grosen, K, Tankisi, H, Charles, M, Andersen, N T, Andersen, H, Petropoulos, I N, Malik, R A, Jensen, T S & Karlsson, P 2018, ' Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes : ADDITION-Denmark ', Journal of Diabetes and its Complications, vol. 32, no. 12, pp. 1153-1159 . https://doi.org/10.1016/j.jdiacomp.2018.09.016 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2018.09.016 |
| Popis: | AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures. |
| Databáze: | OpenAIRE |
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