Synthesis and biological activity of a novel fungicide, pyraziflumid
| Autor: | Nobutaka Kuroki, Masatsugu Oda, Yoshihiro Matsuzaki, Motohiro Hasebe, Yukio Morishita, Takashi Furuya |
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| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
Trifluoromethyl Health Toxicology and Mutagenesis Biological activity 01 natural sciences Combinatorial chemistry Fungicide 010602 entomology Broad spectrum chemistry.chemical_compound chemistry Insect Science 0103 physical sciences Original Article 010306 general physics Lead compound |
| Zdroj: | Journal of pesticide science. 42(4) |
| ISSN: | 1348-589X |
| Popis: | Pyraziflumid was discovered as a novel SDHI fungicide chemically characterized by the 3-(trifluoromethyl)pyrazine-2-carboxamide group. This chemical series showed particularly high fungicidal activities against a broad spectrum of plant diseases in the case of N-(biphenyl-2-yl) as well as N-(1,1,3-trimethylindan-4-yl)carboxamides. Various N-(biphenyl-2-yl)pyrazine-2-carboxamides were synthesized, and their structure-activity relationships were studied. The optimization of the fungicidal performance of the series finally led to the identification of pyraziflumid, which could control a wide range of plant diseases. In this report, details of the structure-activity relationships from the lead compound to pyraziflumid are described. |
| Databáze: | OpenAIRE |
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