Additional file 1 of X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease

Autor: Gromova, Anastasia, Cha, Byeonggu, Robinson, Erica M., Strickland, Laura M., Nguyen, Nhat, ElMallah, Mai K., Cortes, Constanza J., La Spada, Albert R.
Rok vydání: 2023
DOI: 10.6084/m9.figshare.23290390.v1
Popis: Additional file 1. Figure S1: Characterization of body weight of male wildtype and HSA-Cre only controls compared to singly transgenic BAC fxAR121 and muscle-rescued BAC fxAR121;HSA-Cre mice. A) Weight of individual animals of each genotype plotted as a function of time and fitted with a simple linear regression. Slopes and R squared values are as follows: wildtype, HSA-Cre, HSA/fxAR121, fxAR121. B) Gross anatomical analysis upon dissection of agedmale mice showing robust inguinal, epidydimal, and mesenteric white adipose deposits in control miceand the complete absence of these deposits in BAC fxAR121; HSA-Cre mice.
Databáze: OpenAIRE