Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
| Autor: | Aušra Voskienė, Rita Kazernavičiūtė, Ramūnė Kolosej, Ilona Jonuškienė, Petras Rimantas Venskutonis, Jūratė Šiugždaitė, Zita Brazienė, Vytautas Mickevičius, Elena Jakienė |
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| Přispěvatelé: | MDPI AG (Basel, Switzerland) |
| Rok vydání: | 2013 |
| Předmět: |
Pharmaceutical Science
Hydrazone biological activity Microbial Sensitivity Tests Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound hydrazone lcsh:Organic chemistry Oil content Drug Discovery Combinatorial Chemistry Techniques Organic chemistry Physical and Theoretical Chemistry Thiazole Nuclear Magnetic Resonance Biomolecular chemistry.chemical_classification Molecular Structure Brassica rapa Fatty Acids Organic Chemistry N-phenyl-N-thiocarbamoyl-β-alanine hantzsch synthesis thiazole Biological activity Hantzsch synthesis Antimicrobial Anti-Bacterial Agents Propanoic acid chemistry Chemistry (miscellaneous) Yield (chemistry) Molecular Medicine 615.28 [udc] Propionates |
| Zdroj: | Molecules, Vol 18, Iss 12, Pp 15000-15018 (2013) Molecules, Basel : MDPI, 2013, vol. 18, iss. 12, p. 15000-15018 Molecules; Volume 18; Issue 12; Pages: 15000-15018 Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules181215000 |
| Popis: | New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content. |
| Databáze: | OpenAIRE |
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