Does the KIR2DS5 gene protect from some human diseases?
| Autor: | Marian Klinger, Maciej Kurpisz, Edyta Majorczyk, Ji-Yao Sun, Jacek R. Wilczyński, Ewa Barcz, Henryk Tchórzewski, Piotr Wiland, Izabela Nowak, Andrzej Malinowski, Rafał Płoski, Maria Magott-Procelewska, Arkadiusz Chlebicki, Jacek Malejczyk, Aleksandra Zoń-Giebel, Renata Jankowska, Ewa Passowicz-Muszyńska, David Senitzer, Sebastian Giebel, Andrzej Pawlik, Wioleta Łuszczek, Piotr Kuśnierczyk, Andrzej Wiśniewski, Marian Gryboś |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_treatment Endometriosis Immunology/Autoimmunity lcsh:Medicine Hematopoietic stem cell transplantation Natural killer cell Young Adult Gene Frequency Receptors KIR Genetics and Genomics/Population Genetics medicine Humans Disease Spondylitis Ankylosing Immunology/Reproductive Immunology Receptor lcsh:Science Gene Allele frequency Genetics and Genomics/Genetics of Disease Aged Genetics and Genomics/Medical Genetics Aged 80 and over Multidisciplinary business.industry lcsh:R Middle Aged Ligand (biochemistry) medicine.disease Transplant rejection medicine.anatomical_structure Immunology Cancer research Genetics and Genomics/Genetics of the Immune System Female lcsh:Q business Immunology/Genetics of the Immune System Research Article |
| Zdroj: | PLoS ONE, Vol 5, Iss 8, p e12381 (2010) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. Methodology/Principal Findings In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p = 0.003, odds ratio [OR] = 0.47, confidence interval [CI] = 0.28–0.79), endometriosis (p = 0.03, OR = 0.25, CI = 0.07–0.82) and acute rejection of kidney graft (p = 0.0056, OR = 0.44, CI = 0.24–0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p>0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p = 0.0003, OR = 0.35, CI = 0.19–0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p = 0.0017, OR = 1.92, CI = 1.28–2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p = 0.005, OR = 1.47, CI = 1.13–1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p = 0.017, OR = 0.47, CI = 0.25–0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p = 0.0015, OR = 2.13, CI = 1.34–3.37). Conclusions/Significance Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. |
| Databáze: | OpenAIRE |
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