Preconception exposure to dietary levels of genistein affects female reproductive outcomes
| Autor: | James A. Hartman, Jodi A. Flaws, Shreya Patel, William G. Helferich |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Litter (animal) medicine.medical_specialty Litter Size media_common.quotation_subject Physiology Genistein Phytoestrogens Fertility Biology Toxicology Article Mice 03 medical and health sciences chemistry.chemical_compound Pregnancy Internal medicine medicine Animals Progesterone media_common Estradiol Reproduction Body Weight Ovary Uterus Organ Size medicine.disease Diet Pregnancy rate 030104 developmental biology Endocrinology Liver chemistry Gestation Female Hormone |
| Zdroj: | Reproductive Toxicology. 74:174-180 |
| ISSN: | 0890-6238 |
| Popis: | Genistein is a phytoestrogen found in soy and soy-based products. Previously, we found that genistein adversely affected estradiol levels and follicle growth in vitro. Proper hormone production and follicle growth are key regulators of normal fertility. Therefore, we hypothesized that genistein adversely affects female fertility and pregnancy outcomes. To test this hypothesis, we dosed sexually mature female CD-1 mice (35 days) with 0, 300, 500, or 1000 ppm genistein for 30, 60, 150, and 240 days. At the end of the dosing periods, we measured mating rate, pregnancy rate, fertility rate, gestation time, parturition time, pup mortality, litter size, average pup weight, and estradiol and progesterone levels. We found that chronic, preconception exposure to genistein affects gestation time, parturition time, litter size, pup weight, and pup mortality. Additionally, genistein exposure for 240 days appears to have a protective effect on fertility rate, but does not affect hormone levels in vivo. |
| Databáze: | OpenAIRE |
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