pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers
| Autor: | Ubiratan de Paula Santos, Thamires Marques de Lima, Paulo Hilário Nascimento Saldiva, Carmen Diva Sadiva de André, Ana Luisa Godoy Fernandes, Maria Lucia Bueno-Garcia, Pieter S. Hiemstra, Cristiane Mayumi Kazama, Andreas Rembert Koczulla, Mariangela Macchione, Dirce Maria Trevisan Zanetta, Naomi Kondo Nakagawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adolescent Air pollution Airway Inflammation medicine.disease_cause Young Adult Risk Factors Air Pollution Occupational Exposure Medicine Humans Exhaled breath condensate lcsh:R5-920 Carbon Monoxide Lung business.industry Exhalation Reproducibility of Results General Medicine Pneumonia Clinical Science Hydrogen-Ion Concentration Middle Aged Exhaled Breath Condensate Nasal Lavage Fluid medicine.anatomical_structure Cross-Sectional Studies Breath Tests Anesthesia Nasal Lavage Biomarker (medicine) Cytokines Particulate Matter Airway business lcsh:Medicine (General) Biomarkers |
| Zdroj: | Clinics Clinics, Vol 68, Iss 12, Pp 1488-1494 (2013) Clinics, Volume: 68, Issue: 12, Pages: 1488-1494, Published: DEC 2013 Clinics, 68(12), 1488-1494 Clinics; v. 68 n. 12 (2013); 1488-1494 Clinics; Vol. 68 Núm. 12 (2013); 1488-1494 Clinics; Vol. 68 No. 12 (2013); 1488-1494 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1β and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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