Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men
| Autor: | Arnulf Ferlitsch, Elisabeth Fasching, Irina GessI, Elisabeth Waldmann, Bernd Jilma, Michael Kundi, Philip Jeschek, Martha Britto-Arias, Daniela Sallinger, Georg Heinze, P. Salzl, Monika Ferlitsch, Michael Trauner |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Adenoma Cross-sectional study Epidemiology Prevalence colorectal adenomas screening colonoscopy 03 medical and health sciences 0302 clinical medicine Breast cancer Sex Factors Interquartile range Risk Factors Internal medicine gender Medicine Humans Risk factor Aged Cervical cancer business.industry Incidence (epidemiology) Middle Aged medicine.disease colorectal cancer prevention Cross-Sectional Studies 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology advanced adenomas Female business Colorectal Neoplasms Precancerous Conditions |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact of risk factors. Methods: A cross-sectional study analysing health check-up examinations and screening colonoscopies performed within a national quality assurance program. Results: A total of 25 409 patients were included in this study, 50.8% were women. Median age for both sexes was 60 years (interquartile range (IQR) 54–67). A multivariable model showed that risk factors mediated only 0.6 of the 10.4% gender gap in adenoma and 0.47 of the 3.2% gender gap in advanced adenoma detection rate. Smoking was the only independent risk factor with a varying sex-specific effect (men OR 1.46, CI 1.29, 1.64, women OR 1.76, CI 1.53, 2.06) and advanced adenomas (men OR 1.06, CI 0.80–1.42; women OR 2.08, CI 1.52–2.83). Independent risk factors for adenomas were BMI (OR 1.35 per IQR, CI 1.25–1.47) and triglyceride level (OR 1.03 per IQR, CI 1.00–1.06); for advanced adenomas physical activity (none vs regular: OR 1.54, CI 1.18–2.00, occasional vs regular: OR 1.17, CI 1.00–1.38), cholesterol level (OR 1.13 per IQR, CI 1.02–1.25), blood glucose level (OR 1.05 per IQR, CI 1.01–1.09) and alcohol score (OR 1.09 per IQR, CI 1.01–1.18). Conclusions: Risk factors cannot explain higher prevalence rates in men. Results of this study strongly underline the need for sex-specific screening recommendations. |
| Databáze: | OpenAIRE |
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