Probiotic Effects of Feeding Heat-Killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-Colonized Immunodeficient Mice
| Autor: | M Dohnalek, Hilty M, Edward Balish, R D Wagner, Thomas F. Warner, C Pierson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Lactobacillus casei
Hot Temperature Gram-positive bacteria Mice Nude Microbiology law.invention Mice Probiotic Lactobacillus acidophilus law Candida albicans medicine Animals Germ-Free Life biology Probiotics Body Weight Candidiasis food and beverages biology.organism_classification medicine.disease Disseminated Candidiasis Corpus albicans Lacticaseibacillus casei Immunology Systemic candidiasis Digestive System Spleen Food Science |
| Zdroj: | Journal of Food Protection. 63:638-644 |
| ISSN: | 0362-028X |
| DOI: | 10.4315/0362-028x-63.5.638 |
| Popis: | Probiotic bacteria can protect immunodeficient mice from orogastric candidiasis but cause some pathology of their own. Severely immunodeficient patients may be at risk if fed viable probiotics, so this study evaluated the probiotic potential of nonviable probiotic bacteria to protect immunodeficient mice from Candida albicans infections. Heat-killed probiotic bacteria were fed to gnotobiotic bg/bg-nu/nu and bg/bg-nu/+ mice to ascertain if they could protect the mice from mucosal and systemic candidiasis. Both heat-killed Lactobacillus acidophilus (HKLA) and heat-killed Lactobacillus casei (HKLC), in comparison to control mice not fed the probiotic bacteria but challenged (oral) with C. albicans, suppressed the severity of orogastric candidiasis in bg/bg-nu/nu mice at 2 weeks after colonization with C. albicans, inhibited disseminated candidiasis in C. albicans-colonized bg/bg-nu/+ mice at 4 weeks after colonization, and suppressed the number of viable C. albicans in the alimentary tract. HKLA, but not HKLC, treatment inhibited disseminated candidiasis in bg/bg-nu/nu mice at 2 weeks after oral challenge and enhanced the proliferative responses of splenocytes from C. albicans-colonized bg/bg-nu/+ mice to C. albicans antigens. Neither HKLA nor HKLC were able to prolong the survival of gnotobiotic bg/bg-nu/nu mice after oral challenge with C. albicans. These results demonstrate that heat-killed lactobacilli can induce some (limited) protection (probiotic effect) against candidiasis in mice. |
| Databáze: | OpenAIRE |
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