Asymmetric Hydrogenation of Azaindoles: Chemo‐ and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes
| Autor: | Kentaro Ishizuka, Yusuke Makida, Ryoichi Kuwano, Takahiro Kuramoto, Masahiro Saita |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element General Medicine General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences Ruthenium chemistry.chemical_compound chemistry Organic chemistry Enantiomer Chemoselectivity Phosphine |
| Zdroj: | Angewandte Chemie International Edition. 55:11859-11862 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201606083 |
| Popis: | High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η(3) -methallyl)2 (cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text