Selection of patients for bone marrow transplantation in severe aplastic anemia
| Autor: | B M, Camitta, J M, Rappeport, R, Parkman, D G, Nathan |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Graft Rejection Immunosuppression Therapy Time Factors Adolescent Radiotherapy Immunology Anemia Aplastic Bone Marrow Cells Bone Marrow Examination Cell Biology Hematology Biochemistry Histocompatibility Procarbazine Androgens Humans Transplantation Homologous Child Cyclophosphamide Antilymphocyte Serum Bone Marrow Transplantation |
| Zdroj: | Blood. 45:355-363 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Despite androgens and intensive supportive care, satisfactory survival in severe aplastic anemia remains at 20% or less. Histocompatible bone marrow transplantation can restore normal hematopoiesis in approximately 40% of similarly severe individuals. Delay of transplantation for 3 wk after diagnosis allows time for proper evaluation and for many spontaneous recoveries. Further delay increases risks of fatal complications and decreases chances for successful transplantation while the incidence of spontaneous remission declines. When available, early histocompatible bone marrow transplantation may be the treatment of choice for severe aplastic anemia. |
| Databáze: | OpenAIRE |
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