The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up

Autor:	D. Shaw, Kenneth Bridges, D. Gardner, A. Platt, A. Brenner, S. Valdez, F. Danny Armstrong, J. Chow, Brian Adler, Margaret Telfer, S. Gargiulo, D. Peace, R. O'Brien, Wendell F. Rosse, Maureen Okam, D. Davies, A. Davis, S. Claster, V. Knors, P. Ryans, D. Temple, L. White, Timothy M. Carlos, Susan B. Shurin, R. Harrell, Y. Barber, K. Williams, K. Chiarucci, E. Case, Elliott Vichinsky, Charles H. Pegelow, N. Lewis, P. Gascon, J. Siteman, Carolyn Bigelow, B. Tynan, A. Palmer, T. Saunders, P. Di Paolo, Rita Bellevue, K. Genther, B. Schmidt, W. Labrousse, O. C. Onyekwere, G. Pendarvis, C. Hoehner, D. Strayhorn, A. Anderson, M. McGee, Nancy F. Olivieri, A. Tracy, Yogen Saunthararajah, Wally R. Smith, Kenneth I. Ataga, J. Braddock, Brian W. Berman, Ward Hagar, Stephen H. Embury, Elyse Mandell, Lisa Daitch, M. Hui, V. Sabahi, A. Johnson-Telfair, Myron A. Waclawiw, Samir K. Ballas, A. Roundtree-Schmotzer, T. McArdle, L. Waller, L. Eskridge, B. Maddox, M. Bryan, L. Usry, N. Talischy-Zahed, Paul F. Milner, J. H. Bailey, Abdullah Kutlar, Elliott Perlin, Josef T. Prchal, M. Sheikhai, E. M. Rodriguez, Oswaldo Castro, E. Hackney-Stevens, L. Dorn, G. E. Allen, L. Keverline, S. Hernandez, K. McLaughlin, A. Earles, Harvey Dosik, Martin H. Steinberg, E. Carter-Randall, Helga Finke, J. Moshang, Laura DeCastro, T. Harrington, E. Wilkes, C. Winograd, H. Souffrant, S. Childerie, G. Ramirez, Eugene P. Orringer, William F. McCarthy, B. Scott, Paul Swerdlow, Mabel Koshy, James R. Eckman, K. Kleman, George Phillips, C. Nwokolo, Susan Jones
Rok vydání:	2010
Předmět:	Adult Lung Diseases Male medicine.medical_specialty Pediatrics Adolescent Anemia Anemia Sickle Cell Risk Assessment Statistics Nonparametric law.invention Young Adult Randomized controlled trial law Neoplasms Sepsis medicine Humans Hydroxyurea Prospective Studies Practice Patterns Physicians' Intensive care medicine Prospective cohort study Survival analysis business.industry Liver Diseases Mortality rate Hematology Middle Aged medicine.disease Survival Analysis Drug Utilization Sickle cell anemia Stroke Clinical trial Early Termination of Clinical Trials Cohort Female Kidney Diseases business DNA Damage Follow-Up Studies
Zdroj:	American Journal of Hematology.
ISSN:	1096-8652 0361-8609
DOI:	10.1002/ajh.21699
Popis:	A randomized, controlled clinical trial established the efficacy and safety of short-term use of hydroxyurea in adult sickle cell anemia. To examine the risks and benefits of long-term hydroxyurea usage, patients in this trial were followed for 17.5 years during which they could start or stop hydroxyurea. The purpose of this follow-up was to search for adverse outcomes and estimate mortality. For each outcome and for mortality, exact 95% confidence intervals were calculated, or tests were conducted at alpha = 0.05 level (P-value
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a02ee45e906d4bcf68559bb23f32a https://doi.org/10.1002/ajh.21699 Zobrazit plný text záznamu Plný text