Effect of Neonatal Rat Bisphenol a Exposure on Performance in the Morris Water Maze
| Autor: | B. Scott Gandy, Peter L. Ryan, Frances R. Bertasi, Russell L. Carr, Scott T. Willard, Susan D. Bowers, Angela M. Betancourt |
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| Rok vydání: | 2003 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Dose Offspring Health Toxicology and Mutagenesis Administration Oral Morris water navigation task Toxicology chemistry.chemical_compound Sex Factors Phenols Memory Oral administration Internal medicine Animals Medicine Estrogens Non-Steroidal Benzhydryl compounds Benzhydryl Compounds Maze Learning Swimming urogenital system business.industry Rats Inbred F344 Teratology Rats Endocrinology Endocrine disruptor chemistry Space Perception Toxicity Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 66:2077-2088 |
| ISSN: | 1528-7394 |
| DOI: | 10.1080/713853983 |
| Popis: | Bisphenol A (BPA), an environmental estrogen, is a component of many food and beverage containers and can leach into the container contents over time. Due to its estrogenic properties, exposure to BPA during development could alter the appropriate maturation of pathways essential for normal cognitive function at later ages. To investigate this, the effects of repeated postnatal exposure of male and female rats to BPA on spatial learning and memory were investigated using a Morris water maze. Breeders and offspring were maintained on a standard phytoestrogen-free diet. Oral administration of 72 microg/kg 17 beta-estradiol (E(2)), 100 microg/kg BPA (low BPA), 250 microg/kg BPA (high BPA), or the safflower oil vehicle was performed daily from postnatal d 1 (PND1) through PND14. There were no treatment-related effects on swimming ability or motivation (PND33) or on acquisition of maze solution (PND34-37). However, acquisition of maze performance was significantly better in control males than in control females. Treatment with E(2) and low BPA disrupted this normal gender-dependent pattern of acquisition, while treatment with high BPA did not. In a probe trial (PND40), females treated with high BPA spent significantly less time in the escape quadrant. These data indicate that E(2) and low dosages of BPA can alter the normal gender-dependent pattern of acquisition, while higher dosages of BPA alter the retention of spatial information without significantly affecting acquisition. |
| Databáze: | OpenAIRE |
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