Determination of a newly encountered designer drug 'p-methoxyethylamphetamine' and its metabolites in human urine and blood
| Autor: | Takeshi Hayashi, Kei Zaitsu, Hitoshi Tsuchihashi, Noriaki Shima, Hiroe Kamata, Ryoji Matoba, Munehiro Katagi, Tooru Kamata, Hisanaga Kuroki |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Chromatography medicine.drug_class business.industry Amphetamines Ms analysis Postmortem blood Urine Gas Chromatography-Mass Spectrometry Designer Drugs Methamphetamine Pathology and Forensic Medicine Designer drug Forensic Toxicology Blood concentration medicine Humans Urine specimen Central Nervous System Stimulants Drug intoxication business Law Demethylation |
| Zdroj: | Forensic Science International. 177:77-84 |
| ISSN: | 0379-0738 |
| Popis: | A newly synthesized designer drug, para -methoxyethylamphetamine (PMEA) was unexpectedly detected in the postmortem specimens of fatality involving drug intoxication in 2005, Japan. For unequivocal identification, the isomeric discrimination of PMEA and its positional-isomers was performed by GC/MS with the trifluoroacetylation. In order to prove the intake of PMEA, the characteristic metabolites of PMEA were also identified by GC/MS analysis of the urine specimen with trifluoroacetylation. As a result, para -methoxyamphetamine, para -hydroxyethylamphetamine (POHEA) and para -hydroxyamphetamine were identified as the major metabolites of PMEA. For the quantitative analyses of PMEA and its three metabolites in body fluids, an automated column-switching LC/MS procedure was developed, and applied to the postmortem blood and urine specimens. In this fatal case, blood concentration of PMEA was estimated to be 12.2μg/mL and this level seemed extremely high in comparison with lethal blood-levels of its analogues, representing acute-intoxication of the victim. Based on the quantitative results, PMEA was found to be extensively metabolized to POHEA via O -demethylation, partly followed by its conjugation. |
| Databáze: | OpenAIRE |
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