Noscapine inhibits tumor growth in TMZ-resistant gliomas
| Autor: | Stan G. Louie, Nicos A. Petasis, Niyati Jhaveri, Axel H. Schönthal, Hee-Yeon Cho, Thomas C. Chen, Shering Torres, Weijun Wang, Florence M. Hofman |
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| Rok vydání: | 2011 |
| Předmět: |
Noscapine
Drug Cancer Research media_common.quotation_subject Mice Nude Antineoplastic Agents Glioma cell Mice Glioma Temozolomide medicine Animals Humans Tumor growth media_common Antitumor activity Brain Neoplasms business.industry medicine.disease Xenograft Model Antitumor Assays nervous system diseases Dacarbazine Oncology Drug Resistance Neoplasm Cancer research Female Glioblastoma business Cell Division medicine.drug |
| Zdroj: | Cancer Letters. 312:245-252 |
| ISSN: | 0304-3835 |
| Popis: | Noscapine, a common oral antitussive agent, has been shown to have potent antitumor activity in a variety of cancers. Treatment of glioblastoma multiforme (GBM) with temozolomide (TMZ), its current standard of care, is problematic because the tumor generally recurs and is then resistant to this drug. We therefore investigated the effects of noscapine on human TMZ-resistant GBM tumors. We found that noscapine significantly decreased TMZ-resistant glioma cell growth and invasion. Using the intracranial xenograft model, we showed that noscapine increased survival of animals with TMZ-resistant gliomas. Thus noscapine can provide an alternative therapeutic approach for the treatment of TMZ-resistant gliomas. |
| Databáze: | OpenAIRE |
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