Harnessing the therapeutic potential of extracellular vesicles for cancer treatment
| Autor: | Gaoge Sun, Ying Zhang, Lerui Guo, Xue Jin, Hang Yin, Tian Li, Yu Xiao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Bioinformatics Metastasis Targeted therapy 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Drug Delivery Systems Neoplasms medicine Animals Humans Drug Carriers business.industry Cancer Immunotherapy Extracellular vesicle medicine.disease Radiation therapy Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis business Chemoradiotherapy |
| Zdroj: | Seminars in cancer biology. 74 |
| ISSN: | 1096-3650 |
| Popis: | Cancer therapeutic strategies include surgeries, radiotherapy, chemotherapy, targeted therapy and immunotherapies. However, current cancer treatment still faces challenges such as postoperative residuals, postoperative recurrence, chemoradiotherapy resistance and lack of drugs with high specificity, due to the complexity of the cancer environment. Extracellular vesicles (EVs) are lipid-capsuled membrane vesicles secreted from cells, communicating vital messages between cells and regarding function in tumorigenesis and metastasis. Investigation of compositions and functions of EVs may open unprecedented, promising avenues for cancer therapeutics. This review brings new perspectives from both researchers and clinicians in the EV field, emphasizing the ties between basic research and ongoing clinical trials. In sum, our review summarizes the roles EVs play in cancer therapy, ranging from mechanisms to applications in cancer treatment. In particular, it focuses on their therapeutic potential with an eye toward clinical relevance. |
| Databáze: | OpenAIRE |
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