Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6months in a nonhuman primate neonate model
| Autor: | S. Tyler Aycock, Matthew J. Jorgensen, S. Bruce King, Ralph B. D'Agostino, Mallinath B. Hadimani, Beth C. Holbrook, Martha A. Alexander-Miller |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Primates Influenza vaccine medicine.medical_treatment Biology Antibodies Viral Neutralization Virus Article 03 medical and health sciences 0302 clinical medicine Immune system Adjuvants Immunologic Orthomyxoviridae Infections Chlorocebus aethiops medicine Animals General Veterinary General Immunology and Microbiology Vaccination Public Health Environmental and Occupational Health Orthomyxoviridae Virology 030104 developmental biology Infectious Diseases Immunization Animals Newborn Vaccines Inactivated Influenza Vaccines Immunology Antibody Formation biology.protein Molecular Medicine Antibody Adjuvant 030215 immunology |
| Zdroj: | Vaccine. 35(45) |
| ISSN: | 1873-2518 |
| Popis: | Generation of a potent antibody response that can be sustained over time is highly challenging in young infants. Our previous studies using a nursery-reared nonhuman primate model identified R848 conjugated to inactivated influenza virus as a highly immunogenic vaccine for neonates. Here we determined the effectiveness of this vaccine in mother-reared infants as well as its ability to promote improved responses at 6 months compared to vaccination in the absence of R848. In agreement with our nursery study, R848 conjugated to influenza virus induced a higher antibody response in neonates compared to the non-adjuvanted vaccine. Further, the increase in the response relative to that induced by the non-adjuvanted vaccine was maintained at 6 months suggesting the increased antibody secreting cells that resulted from inclusion of conjugated R848 production were capable of surviving long term. There was no significant difference in quality of antibody (i.e. neutralization or affinity), suggesting the beneficial effect of conjugated R848 during vaccination of neonates with inactivated influenza virus is likely manifest during the early generation of antibody secreting cells. |
| Databáze: | OpenAIRE |
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