Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment - A Multicenter DTI and Volumetry Study
| Autor: | Elisabeth Kasper, Frederik Barkhof, Michel J. Grothe, Karlheinz Hauenstein, Stefan J. Teipel, Katharina Brueggen, Massimo Filippi, Lucrezia Hausner, Martin Dyrba, Peter J. Nestor, Stefan Klöppel |
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| Přispěvatelé: | Brueggen, K, Dyrba, M, Barkhof, F, Hausner, L, Filippi, Massimo, Nestor, Pj, Hauenstein, K, Klöppel, S, Grothe, Mj, Kasper, E, Teipel, Sj, Radiology and nuclear medicine, NCA - neurodegeneration |
| Rok vydání: | 2015 |
| Předmět: |
Male
pathology [Cognitive Dysfunction] International Cooperation Hippocampus Neuropsychological Tests Aged 80 and over Basal forebrain medicine.diagnostic_test General Neuroscience diagnosis [Alzheimer Disease] complications [Alzheimer Disease] General Medicine Magnetic Resonance Imaging Europe Psychiatry and Mental health Clinical Psychology Diffusion Tensor Imaging medicine.anatomical_structure Disease Progression Cardiology Female Alzheimer's disease complications [Cognitive Dysfunction] Psychology medicine.medical_specialty Basal Forebrain pathology [Basal Forebrain] Grey matter Statistics Nonparametric Atrophy Alzheimer Disease Predictive Value of Tests Internal medicine mental disorders medicine Humans Dementia Cognitive Dysfunction ddc:610 Aged Magnetic resonance imaging medicine.disease pathology [Hippocampus] nervous system Geriatrics and Gerontology Mental Status Schedule Neuroscience Diffusion MRI |
| Zdroj: | Brueggen, K, Dyrba, M, Barkhof, F, Hausner, L, Filippi, M, Nestor, P J, Hauenstein, K, Kloppel, S, Grothe, M J, Kasper, E & Teipel, S J 2015, ' Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment-A Multicenter DTI and Volumetry Study ', Journal of Alzheimer's Disease, vol. 48, no. 1, pp. 197-204 . https://doi.org/10.3233/JAD-150063 Journal of Alzheimer's disease 48(1), 197-204 (2015). doi:10.3233/JAD-150063 Journal of Alzheimer's Disease, 48(1), 197-204. IOS Press |
| ISSN: | 1387-2877 |
| Popis: | Background: Hippocampal grey matter (GM) atrophy predicts conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Pilot data suggests that mean diffusivity (MD) in the hippocampus, as measured with diffusion tensor imaging (DTI), may be a more accurate predictor of conversion than hippocampus volume. In addition, previous studies suggest that volume of the cholinergic basal forebrain may reach a diagnostic accuracy superior to hippocampal volume in MCI. Objective: The present study investigated whether increased MD and decreased volume of the hippocampus, the basal forebrain and other AD-typical regions predicted time to conversion from MCI to AD dementia. Methods: 79 MCI patients with DTI and T1-weighted magnetic resonance imaging (MRI) were retrospectively included from the European DTI Study in Dementia (EDSD) dataset. Of these participants, 35 converted to AD dementia after 6-46 months (mean: 21 months). We used Cox regression to estimate the relative conversion risk predicted by MD values and GM volumes, controlling for age, gender, education and center. Results: Decreased GM volume in all investigated regions predicted an increased risk for conversion. Additionally, increased MD in the right basal forebrain predicted increased conversion risk. Reduced volume of the right hippocampus was the only significant predictor in a stepwise model combining all predictor variables. Conclusion: Volume reduction of the hippocampus, the basal forebrain and other AD-related regions was predictive of increased risk for conversion from MCI to AD. In this study, volume was superior to MD in predicting conversion. |
| Databáze: | OpenAIRE |
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