Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans
Autor: | William Maixner, Jeffrey S. Mogil, D.C. Brown, B.D.X. Lascelles |
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Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
040301 veterinary sciences Companion animal Biomedical Engineering Translational research Disease Translational Research Biomedical 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Human disease Drug Development Rheumatology Osteoarthritis medicine Animals Humans Pain Management Orthopedics and Sports Medicine business.industry Chronic pain Outcome measures Pets 04 agricultural and veterinary sciences medicine.disease Arthritis Experimental Surgery Drug development Narrative review Chronic Pain business Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Osteoarthritis and Cartilage. 26:175-183 |
ISSN: | 1063-4584 |
Popis: | Summary Objective To outline the role that spontaneous osteoarthritis (OA) in companion animals can play in translational research and therapeutic pharmacological development. Outline Narrative review summarizing the opportunities and limitations of naturally occurring, spontaneous OA as models of human OA pain, with a focus on companion animal pets. The background leading to considering inserting spontaneous disease models in the translational paradigm is provided. The utility of this model is discussed in terms of outcome measures that have been validated as being related to pain, and in terms of the potential for target discovery is outlined. The limitations to using companion animal pets as models of human disease are discussed. Conclusions Although many steps along the translational drug development pathway have been identified as needing improvement, spontaneous painful OA in companion animals offers translational potential. Such ‘models' may better reflect the complex genetic, environmental, temporal and physiological influences present in humans and current data suggests the predictive validity of the models are good. The opportunity for target discovery exists but is, as yet, unproven. |
Databáze: | OpenAIRE |
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