Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase

Autor:	Tomas Kucera, Lucie Nováková, Jan Korábečný, Eliška Kohelová, Abdullah Al Mamun, Jiří Kuneš, Aneta Ritomská, Rozálie Peřinová, Tereza Kobrlova, Lucie Cahlíková, Jana Maříková, Daniela Hulcová
Rok vydání:	2020
Předmět:	Models Molecular Aché Stereochemistry Pharmaceutical Science 01 natural sciences Substrate Specificity Analytical Chemistry chemistry.chemical_compound Drug Discovery Humans Potency heterocyclic compounds Butyrylcholinesterase Pharmacology Molecular Structure biology 010405 organic chemistry Chemistry Alkaloid Amaryllidaceae Organic Chemistry Esters biology.organism_classification Acetylcholinesterase language.human_language 0104 chemical sciences Molecular Docking Simulation 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Blood-Brain Barrier Amaryllidaceae Alkaloids language Molecular Medicine Cholinesterase Inhibitors
Zdroj:	Journal of Natural Products. 83:1359-1367
ISSN:	1520-6025 0163-3864
Popis:	A total of 20 derivatives (1–20) of the crinane-type alkaloid ambelline were synthesized. These semisynthetic derivatives were assessed for their potency to inhibit both acetylcholinesterase (AChE)...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b727920822bea5ea1a2ebbf9c21fea8 https://doi.org/10.1021/acs.jnatprod.9b00561 Zobrazit plný text záznamu