Mantle Cell Lymphoma Disguised as Marginal Zone Lymphoma

Autor:	Erica, Jacobson, Peter, Burke, Barbara H, Tindle
Rok vydání:	2005
Předmět:	Aged 80 and over Diagnosis Differential Male Medical Laboratory Technology Lymphoma B-Cell immune system diseases hemic and lymphatic diseases Humans Lymphoma Mantle-Cell General Medicine Aged Pathology and Forensic Medicine
Zdroj:	Archives of Pathology & Laboratory Medicine. 129:929-932
ISSN:	1543-2165 0003-9985
DOI:	10.5858/2005-129-929-mcldam
Popis:	We report a case of mantle cell lymphoma histologically indistinguishable from marginal zone lymphoma. An 83-year-old man presented with a 9.0-cm, slowly enlarging axillary mass. Microscopically, the neoplastic process was largely interfollicular, surrounding residual follicular centers, some of which had discernible small lymphocyte mantles. Overall, the morphologic pattern was highly suggestive of marginal zone lymphoma. However, flow cytometric and immunohistochemical results, including cyclin D1 positivity, revealed an immunophenotype that fit with mantle cell lymphoma. The differential diagnosis of mantle cell lymphoma is broad, and it is well known that mantle cell lymphoma can assume a number of histologic appearances, including, infrequently, that of more indolent B-cell non-Hodgkin lymphomas. Although not pathognomonic, cyclin D1 positivity is highly specific for mantle cell lymphoma and is key in distinguishing these clinically dissimilar malignant lymphomas. In recent years, detection of cyclin D1 has expanded the recognizable histologic spectrum of mantle cell lymphoma.
Databáze:	OpenAIRE
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