Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes
| Autor: | Yee Suh Teh, Edward F. Nash, Sabba Chaudhry, Joht Singh Chandan, Syed Noman Atta, Punith Kempegowda, Prashant Amrelia, Harbinder Sunsoa, Sidrah Amir, Joanna L. Whitehouse, Ateeq Syed, Lauren Quinn, Anne de Bray, Rifat Rashid |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:RC648-665 business.industry Endocrinology Diabetes and Metabolism Cystic fibrosis-related diabetes 030209 endocrinology & metabolism Retrospective cohort study medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology Cystic fibrosis Nephropathy 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine Diabetes mellitus Medicine Microalbuminuria business Retinopathy |
| Zdroj: | Therapeutic Advances in Endocrinology and Metabolism, Vol 11 (2020) |
| ISSN: | 2042-0196 2042-0188 |
| DOI: | 10.1177/2042018820966428 |
| Popis: | Aims: To study the prevalence of microvascular complications and renal changes associated with cystic fibrosis-related diabetes (CFRD). Methods: This retrospective cohort study was conducted at the West Midlands Adult Cystic Fibrosis centre, United Kingdom. Data regarding age, sex, microalbuminuria, retinopathy neuropathy, and biochemical results were collected for all people with CFRD who had an annual review from 1 January 2018 to 31 December 2018 at the centre. Descriptive statistics were analysed using STATAv15.1. Results: A total of 189 patients were included, of which 56.6% were male and median age (interquartile range) was 33 (27–39) years; 79.4% (150/189) had their annual review in 2018. Those with a biochemically impaired renal function numbered 7.2% (13/180) and 22.7% (32/141) had microalbuminuria; 17.2% (10/58) had diabetes related retinopathy. No one in our cohort had diabetic ulcers; however, 10.3% (13/126) had absent foot pulses. Conclusion: We found a higher prevalence of microalbuminuria compared with retinopathy in a large cohort of cystic fibrosis adults. This study demonstrates the need for regular specialist follow-up to facilitate early identification of such complications and a long-term prospective cohort to understand underlying mechanisms. |
| Databáze: | OpenAIRE |
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