Controlling complexity: the clinical relevance of mouse complex genetics

Autor: Johan Auwerx, Rudi Balling, Martien Kas, Wim Crusio, Paul Franken, Joan Campbell-Tofte, Klaus Schughart, Jiri Forejt, Jean-Jacques Panthier, Michal Korostynski, Ewelina Knapska, Ana Maria Aransay, Anton Terasmaa, Leszek Kaczmarek, Jan Cendelín
Rok vydání: 2013
Předmět:
Zdroj: European journal of human genetics : EJHG. 21(11)
ISSN: 1476-5438
Popis: Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
Databáze: OpenAIRE