Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index
Autor: | Michael P. Diamond, Heather G. Huddleston, Mary Ellen Pavone, Julie Sroga Rios, Heping Zhang, Gregory M. Christman, Nanette Santoro, Eleni A. Greenwood, Richard S. Legro, Randal D. Robinson, Fangbai Sun, Marcelle I. Cedars |
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Rok vydání: | 2019 |
Předmět: |
Adult
Anti-Mullerian Hormone medicine.medical_specialty Waist endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry 030209 endocrinology & metabolism Context (language use) Biochemistry Body Mass Index 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Humans Medicine Ovarian reserve 030219 obstetrics & reproductive medicine biology business.industry Incidence Insulin Biochemistry (medical) Anti-Müllerian hormone Prognosis Antral follicle Polycystic ovary United States Online Only Cross-Sectional Studies Cardiovascular Diseases Case-Control Studies biology.protein Female business Infertility Female Body mass index Biomarkers Follow-Up Studies Polycystic Ovary Syndrome |
Zdroj: | J Clin Endocrinol Metab |
ISSN: | 1945-7197 0021-972X |
Popis: | Context The relationship between reproductive and cardiometabolic aging is unclear. It is unknown if the relationship differs across different clinical populations. Objective To determine whether markers of ovarian reserve are associated with cardiometabolic risk in reproductive aged women with unexplained infertility (UI), polycystic ovary syndrome (PCOS), and regularly cycling women (OVA). Design and setting Cross-sectional data from 8 US-based academic centers. Participants Women aged 25–40 from 3 clinical populations: 870 with UI, 640 with PCOS, and 921 community-based OVA. Main Outcome Measures Multivariable linear regression models were used to relate anti-mullerian hormone (AMH) and antral follicle count with cardiometabolic parameters including body mass index (BMI), waist circumference (WC), fasting glucose and insulin, homeostasis model assessment-insulin resistance (HOMA-IR), lipids, and C-reactive protein. Results In age and study site-adjusted models, AMH inversely related to BMI in the UI and OVA groups (P = 0.02 and P < 0.001). Among women with PCOS, AMH inversely related to BMI (P < 0.001), and also to WC (P < 0.001), fasting insulin (P < 0.01), HOMA-IR (P < 0.01), triglycerides (P = 0.04), and C-reactive protein (P < 0.001) and directly related to higher total (P = 0.02), low-density lipoprotein (P < 0.01), and high-density lipoprotein cholesterol (P < 0.01). In OVA, AMH also varied inversely with WC (P < 0.001), fasting insulin (P = 0.02), and HOMA-IR (P = 0.02). Adjustment for BMI eliminated associations in the OVA group but in PCOS, the relationship of AMH to total (P = 0.03) and low-density lipoprotein cholesterol (P = 0.003) remained. Conclusion Associations observed between AMH and cardiometabolic indices are largely explained by BMI in women with and without PCOS. (J Clin Endocrinol Metab XX: 0-0, 2019) |
Databáze: | OpenAIRE |
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