Intensive lipid lowering by statin therapy does not improve vasoreactivity in patients with type 2 diabetes
| Autor: | Ton J. Rabelink, Ronald W. van Etten, Marina L. H. Honing, Erik S. G. Stroes, Eelco J.P. de Koning, Carlo A. J. M. Gaillard |
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| Přispěvatelé: | Vascular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Male
Nitroprusside medicine.medical_specialty Serotonin Endothelium Atorvastatin Hemodynamics Vasodilation Hyperlipidemias Type 2 diabetes Nitric Oxide Drug Administration Schedule Internal medicine medicine Humans Pyrroles Prospective Studies Endothelial dysfunction Hypolipidemic Agents business.industry Anticholesteremic Agents Microcirculation Middle Aged medicine.disease Plethysmography Forearm Endocrinology Blood pressure medicine.anatomical_structure Diabetes Mellitus Type 2 Heptanoic Acids Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Dyslipidemia medicine.drug |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology, 22(5), 799-804. Lippincott Williams and Wilkins |
| ISSN: | 1079-5642 |
| Popis: | Cardiovascular disease is the most important cause of morbidity and mortality in patients with type 2 diabetes. Endothelial dysfunction predicts cardiovascular outcome. Type 2 diabetes is characterized by endothelial dysfunction, which may be caused by dyslipidemia. Statin therapy restores endothelial function in hyperlipidemic patients. Therefore, we hypothesize a beneficial effect of atorvastatin on NO-dependent vasodilation in patients with type 2 diabetes and mild dyslipidemia (low density lipoproteins >4.0 mmol/L and/or triglycerides >1.8 mmol/L). We evaluated the effect of intensive lipid lowering (4 weeks of 80 mg atorvastatin once daily) on vasoreactivity in 23 patients with type 2 diabetes by using venous occlusion plethysmography. Twenty-one control subjects were matched for age, sex, body mass index, blood pressure, and smoking habits. The ratio of blood flows in the infused (measurement [M]) and noninfused (control [C]) arm was calculated for each recording (M/C ratio), and M/C% indicates the percentage change from the baseline M/C ratio. Serotonin-induced NO-dependent vasodilation was significantly blunted (52±30 versus 102±66 M/C%, P P P P P |
| Databáze: | OpenAIRE |
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