Clinically relevant potential drug-drug interactions in intensive care patients: a large retrospective observational multicenter study
| Autor: | Bakker, T., Abu-Hanna, A., Dongelmans, D.A., Vermeijden, W.J., Bosman, R.J., Lange, D.W. de, Klopotowska, J.E., Keizer, N.F. de, Hendriks, S., Cate, J. ten, Schutte, P.F., Balen, D. van, Duyvendak, M., Karakus, A., Sigtermans, M., Kuck, E.M., Hunfeld, N.G.M., Sijs, H. van der, Feiter, P.W. de, Wils, E.J., Spronk, P.E., Kan, H.J.M. van, Steen, M.S. van der, Purmer, I.M., Bosma, B.E., Kieft, H., Marum, R.J. van, Jonge, E. de, Beishuizen, A., Movig, K., Mulder, F., Franssen, E.J.F., Bergh, W.M. van den, Bult, W., Hoeksema, M., Wesselink, E., SIMPLIFY Study Grp |
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| Přispěvatelé: | Clinical pharmacology and pharmacy, Elderly care medicine, APH - Aging & Later Life, Anesthesiology, ACS - Microcirculation, Graduate School, Medical Informatics, APH - Quality of Care, APH - Methodology, Intensive Care Medicine, AII - Infectious diseases, APH - Digital Health, Intensive Care, Pharmacy, Clinical Chemistry, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Critical Care health care facilities manpower and services Critical Care and Intensive Care Medicine Clinical decision support system law.invention Medication safety 03 medical and health sciences Patient safety 0302 clinical medicine law Intensive care medicine Humans Clinical significance Drug Interactions Drug-drug interactions Retrospective Studies business.industry Pharmacoepidemiology 030208 emergency & critical care medicine Retrospective cohort study Clinical decision support Intensive care unit Intensive Care Units 030228 respiratory system Pharmaceutical Preparations Emergency medicine Observational study business |
| Zdroj: | Journal of Critical Care, 62, 124-130. W B SAUNDERS CO-ELSEVIER INC Journal of Critical Care, 62, 124-130. Elsevier BV Journal of critical care, 62, 124-130. Elsevier BV on behalf of the SIMPLIFY study group 2021, ' Clinically relevant potential drug-drug interactions in intensive care patients : A large retrospective observational multicenter study ', Journal of Critical Care, vol. 62, pp. 124-130 . https://doi.org/10.1016/j.jcrc.2020.11.020 Journal of Critical Care, 62, 124-130. Elsevier |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2020.11.020 |
| Popis: | Purpose: Potential drug-drug interactions (pDDIs) may harm patients admitted to the Intensive Care Unit (ICU). Due to the patient's critical condition and continuous monitoring on the ICU, not all pDDIs are clinically relevant. Clinical decision support systems (CDSSs) warning for irrelevant pDDIs could result in alert fatigue and overlooking important signals. Therefore, our aim was to describe the frequency of clinically relevant pDDIs (crpDDIs) to enable tailoring of CDSSs to the ICU setting. Materials & methods: In this multicenter retrospective observational study, we used medication administration data to identify pDDIs in ICU admissions from 13 ICUs. Clinical relevance was based on a Delphi study in which intensivists and hospital pharmacists assessed the clinical relevance of pDDIs for the ICU setting. Results: The mean number of pDDIs per 1000 medication administrations was 70.1, dropping to 31.0 when con -sidering only crpDDIs. Of 103,871 ICU patients, 38% was exposed to a crpDDI. The most frequently occurring crpDDIs involve QT-prolonging agents, digoxin, or NSAIDs. Conclusions: Considering clinical relevance of pDDIs in the ICU setting is important, as only half of the detected pDDIs were crpDDIs. Therefore, tailoring CDSSs to the ICU may reduce alert fatigue and improve medication safety in ICU patients. ? 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/). |
| Databáze: | OpenAIRE |
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