Pharmacological Stimulation of Neuronal Plasticity in Acquired Brain Injury
| Autor: | Alim Caelli Fuentes-Bello, Marlene A Rodriguez-Barragan, Paul Carrillo-Mora, Kievka M. Almaguer-Benavides, Juan Manuel Alcantar-Shramm, Julio José Macías-Gallardo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Dopamine Agents Serotonergic 03 medical and health sciences 0302 clinical medicine Memantine Neuroplasticity Brain Injuries Traumatic medicine Amantadine Animals Humans Pharmacology (medical) Intensive care medicine Acquired brain injury Stroke Pharmacology Rehabilitation Evidence-Based Medicine Neuronal Plasticity business.industry Evidence-based medicine Drugs Investigational medicine.disease Combined Modality Therapy Clinical trial Disease Models Animal 030104 developmental biology Brain Injuries Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical neuropharmacology. 40(3) |
| ISSN: | 1537-162X |
| Popis: | Introduction Brain injuries are one of the leading causes of disability worldwide. It is estimated that nearly half of patients who develop severe sequelae will continue with a chronic severe disability despite having received an appropriate rehabilitation program. For more than 3 decades, there has been a worldwide effort to investigate the possibility of pharmacologically stimulating the neuroplasticity process for enhancing the recovery of these patients. Objective The objective of this article is to make a critical and updated review of the available evidence that supports the positive effect of different drugs on the recovery from brain injury. Method To date, there have been several clinical trials that tested different drugs that act on different neurotransmitter systems: catecholaminergic, cholinergic, serotonergic, and glutamatergic. There is both basic and clinical evidence that may support some positive effect of these drugs on motor, cognitive, and language skills; however, only few of the available studies are of sufficient methodological quality (placebo controlled, randomized, blinded, multicenter, etc) to make solid conclusions about their beneficial effects. Conclusions Currently, the pharmacological stimulation of neuroplasticity still does not have enough scientific evidence to make a systematic therapeutic recommendation for all patients, but it certainly is a feasible and very promising field for future research. |
| Databáze: | OpenAIRE |
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