The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms
| Autor: | Slobodanka Djukic, Djordje Radak, Dragana Božić, Ivana Cirkovic, Dario Jocic, Neda Konstantinović |
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| Rok vydání: | 2018 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine 030106 microbiology MRSA Dermatology methicillin-resistant Staphylococcus aureus medicine.disease_cause biofilm Microbiology 03 medical and health sciences VAC therapy medicine Humans Typing Advanced and Specialized Nursing Wound Healing Vacuum assisted closure business.industry SCCmec Biofilm Effective management Staphylococcal Infections biochemical phenomena metabolism and nutrition Methicillin-resistant Staphylococcus aureus 3. Good health dressing change frequency Staphylococcus aureus Biofilms wound infection Wound healing business antibiofilm effect Negative-Pressure Wound Therapy |
| Zdroj: | Advances in Skin & Wound Care |
| ISSN: | 1538-8654 1527-7941 |
| DOI: | 10.1097/01.asw.0000540070.07040.70 |
| Popis: | Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing. |
| Databáze: | OpenAIRE |
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