Dual pH-/thermo-responsive chitosan-based hydrogels prepared using 'click' chemistry for colon-targeted drug delivery applications
| Autor: | Kwon Taek Lim, Sung-Han Jo, Hansol Park, Huong Thi Hoang, Chul-Woong Oh, Quoc-Thang Phan, Sang-Hyug Park |
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| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Cell Survival Acrylic Resins macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences Cell Line Chitosan chemistry.chemical_compound Materials Chemistry Humans Mesalamine Drug Carriers Chemistry Organic Chemistry Polyacrylic acid Temperature technology industry and agriculture Hydrogels Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Polyelectrolyte 0104 chemical sciences Drug Liberation Targeted drug delivery Polymerization Chemical engineering Self-healing hydrogels Drug delivery Click chemistry Click Chemistry 0210 nano-technology Porosity |
| Zdroj: | Carbohydrate Polymers. 260:117812 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2021.117812 |
| Popis: | A dual pH-/thermo-responsive hydrogel was designed based on a polyelectrolyte complex of polyacrylic acid (PAA) and norbornene-functionalized chitosan (CsNb), which was synergized with chemical crosslinking using bistetrazine-poly(N-isopropyl acrylamide) (bisTz-PNIPAM). The thermo-responsive polymeric crosslinker, bisTz-PNIPAM, was synthesized via reversible addition-fragmentation transfer polymerization of NIPAM. FTIR, XRD, rheological and morphological analyses demonstrated the successful formation of the polyelectrolyte network. The highly porous structure generated through the in-situ "click" reaction between Tz and Nb resulted in a higher drug loading (29.35 %). The hydrogel (COOH/NH2 mole ratio of 3:1) exhibited limited drug release (8.5 %) of 5-ASA at a pH of 2.2, but it provided an almost complete release (92 %) at pH 7.4 and 37 °C within 48 h due to the pH responsiveness of PAA, hydrogel porosity, and shrinkage behavior of PNIPAM. The hydrogels were biodegradable and non-toxic against human fibroblast cells, suggesting their considerable potential for a colon-targeted drug delivery system. |
| Databáze: | OpenAIRE |
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