Gamma-aminobutyric acid aggravates nephrotoxicity induced by cisplatin in female rats
| Autor: | Fatemeh Eshraghi-Jazi, Nepton Soltani, Mehdi Nematbakhsh, Elham Peysepar, Ardeshir Talebi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
030110 physiology
0301 basic medicine medicine.medical_specialty Original Urology 030232 urology & nephrology Uterus gamma-Aminobutyric acid Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Blood urea nitrogen Cisplatin Kidney Creatinine business.industry Gamma-aminobutyric acid Gender Malondialdehyde Rats medicine.anatomical_structure Endocrinology chemistry Nephrology business medicine.drug |
| Zdroj: | Journal of Renal Injury Prevention |
| ISSN: | 2345-2781 |
| Popis: | Introduction: Cisplatin (CP) is a major antineoplastic drug for treatment of solid tumors. CP-induced nephrotoxicity may be gender-related. This is while gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system that has renoprotective impacts on acute renal injury. Objectives: This study was designed to investigate the protective role of GABA against CP-induced nephrotoxicity in male and female rats. Materials and Methods: Sixty Wistar male and female rats were used in eight experimental groups. Both genders received GABA (50 μg/kg/day; i. p.) for 14 days and CP (2.5 mg/kg/day; i. p.) was added from day 8 to the end of the study, and they were compared with the control groups. At the end of the study, all animals were sacrificed and the serum levels of blood urea nitrogen (BUN), creatinine (Cr), nitrite, malondialdehyde (MDA), and magnesium (Mg) were measured. The kidney tissue damage was also determined via staining. Results: CP significantly increased the serum levels of Cr and BUN, kidney weight, and kidney tissue damage score in both genders (P |
| Databáze: | OpenAIRE |
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