Sequential Pd 0 ‐ and Pd II ‐Catalyzed Cyclizations: Enantioselective Heck and Nucleopalladation Reactions

Autor:	Jonathan Bajohr, Ramon Arora, Andrew Whyte, Mark Lautens, Alexa Torelli
Rok vydání:	2021
Předmět:	010405 organic chemistry Aryl Enantioselective synthesis chemistry.chemical_element General Chemistry General Medicine 010402 general chemistry Combinatorial chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound Nucleophile chemistry Palladium
Zdroj:	Angewandte Chemie. 133:20393-20398
ISSN:	1521-3757 0044-8249
DOI:	10.1002/ange.202106518
Popis:	An enantioselective consecutive cyclization/coupling process, catalyzed by palladium is reported. Stereoinduction arises from an enantioselective carbopalladation, generating an intermediate which promotes a nucleopalladation step. The dual cyclization sequence was compatible with a variety of alkyne-tethered oxygen- and nitrogen-centered nucleophiles, and a variety of alkenyl-tethered aryl iodides, to forge numerous bisheterocycles in good yields and high regio- and enantioselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5e36a9120d03d6918a1cb213167472 https://doi.org/10.1002/ange.202106518 Zobrazit plný text záznamu Plný text ve formátu PDF